Microscopic Morphology of Brain and Bone Metastases in a Rat Breast Cancer Model by Diffusion MRI
نویسندگان
چکیده
brain metastases (top) had poorly demarcated borders and were highly infiltrative with significant vasogenic edema. In contrast, bone metastases (bottom) had well-demarcated borders and developed as solid masses with minimal infiltration. Brain metastases (n=10) had significantly higher ADC and lower FA values than the normal brain tissue whereas bone metastases (n=5) had a significantly lower ADC than brain metastases. **p < 0.001, *p < 0.05. Figure 1. In vivo DTI before (top) and 4 weeks after (bottom) intracardiac injection of MDA-MB-231-eGFP cells demonstrates multiple breast cancer metastases in the rat brain. Microscopic Morphology of Brain and Bone Metastases in a Rat Breast Cancer Model by Diffusion MRI
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